Emphysema

Home » Emphysema » Risk Factors and Causes

Questions to Ask Your Pulmonary Care Team
(Free Handout)

Risk Factors and Causes

The primary risk factor for emphysema is cigarette smoking. More than 90% of cases occur in people who smoke or have smoked cigarettes (sometimes called "smokers emphysema"). The risk for emphysema increases with the number of cigarettes a person smokes each day and the longer a person smokes. Exposure to second-hand smoke also increases the risk.

Chemicals in cigarette smoke can cause continuous low-grade inflammation in lung tissue. Inflammatory cells release enzymes (i.e., proteins that change the rate of chemical reactions), which break down substances in alveolar walls that maintain the structure and elasticity of the air sacs (e.g., collagen, elastin).

Damage to the alveolar walls limits the ability of the air sacs to shrink during exhalation and increases the size of the alveoli. Eventually, it disrupts the exchange of oxygen and carbon dioxide in lung tissue and increases the size of the lungs, which makes less room in the chest for them to expand during breathing.

Cigarette smoking also increases the effects of other risk factors, including exposure to air pollution, dust, chemicals, and poisonous gases; chronic respiratory infections (e.g., pneumonia, bronchitis); and asthma. People who live in heavily industrialized (urban) areas and people who are exposed to noxious fumes or dust at work may have a higher risk for developing emphysema.

Alpha–1 antitrypsin (AAT), also called alpha-1 protease inhibitor, is an enzyme (protein) that helps to protect lung tissue and allow the alveoli to function properly. People who have a genetic (hereditary) deficiency of alpha-1 antitrypsin are at increased risk for developing alpha-1 antitrypsin deficiency emphysema or familial emphysema.

In this condition, damage to the structure and elasticity of the air sacs occurs unchecked. It is important that people who have this deficiency never smoke. AAT is manufactured in the liver, and patients who have this deficiency also may experience liver damage (e.g., cirrhosis, hepatitis).

© 1998-2008 Healthcommunities.com, Inc. All Rights Reserved.

Emphysema Resources

	Join Our Emphysema Forum Do you have a question, want to share medical advice, or just need to discuss your situation with someone else having a similar experience? The healthchannels forum is a resource for everyone to share and discuss their health and medical needs with others.	Advertising Disclaimer
	Living with...Share your story Do you have a personal health story that you would like to share with others? As a source of free patient education, our goal is to provide our users with trustworthy information and support from others. That's why we've started our "Living with..." sections.
	Our "Living With..." support pages are a place to share experiences about living with a certain condition, disease, disorder, or illness and for loved ones of those dealing with health-related issues. Many people, especially when newly diagnosed, find comfort in knowing that others are having a similar experience. Help others by sharing your story. View stories already submitted.
	Stay Updated Sign up for our newsletter and receive important updates on the medical conditions that are most important to you.
Advertising Disclaimer To quickly access health information from your website's browser, download Healthcommunities.com's healthchannels toolbar. Advertising Disclaimer